郭旭亮 博士 讲师 硕士生导师
主持安徽省自然科学基金,安徽省教育厅重点项目,蚌埠医科大学高层次人才引进经费(一类)等科研项目。分别在ACS Nano, AHM, ACS AMI等杂志上发表研究论文10余篇。博士毕业于天津大学药学院,获应用化学博士学位(药剂学方向)。主要研究方向为肿瘤微环境响应型药物递送系统增效抗肿瘤研究。课题组网站https://www.x-mol.com/groups/xuliangguo
研究方向
1. 肿瘤微环境响应型药物递送系统增效抗肿瘤研究;
2. 基于铁死亡机理的疾病治疗;
3. 其它新型生物材料的研究。
代表性课题
1. 蚌埠医科大学高层次人才引进经费(2021001),2021年-至今,200万,主持
2. 安徽省自然科学基金( 2308085QH304),2023年-至今,8万,主持
3. 安徽省教育厅重点项目(2023AH051930),2023年-至今,10万,主持
代表性论文
1. Xuliang Guo; Fang Liu; Jian Deng; Peipei Dai; Yan Qin; Zhi Li; Bingbing Wang; Aiping Fan; Zheng Wang*; Yanjun Zhao*; Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor eradication. ACS Nano, 2020, 14, 14715-14730. (中科院1区,IF: 17.1)
2. Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, and Xuliang Guo*, Metal-Organic Framework for Hypoxia/ROS/pH Triple-Responsive Cargo Release, Adv. Healthcare Mater. 2023, 12, 2301785. (中科院1区,IF = 10.0)
3. Xuliang Guo , Lefei Han , Wenyu Chen , Huixin He , Weijin Zhang , Chaoqi Huang, Xiu Wang,Hypoxia and Singlet Oxygen Dual-Responsive Micelles for Photodynamic and Chemotherapy Therapy Featured with Enhanced Cellular Uptake and Triggered Cargo Delivery,Int J Nanomedicine. 2024, 19, 247-261. 中科院2区,IF = 8.0)
4. Xuliang Guo; Di Lu; Di Zhang; Jian Deng; Xin Zhang; Zheng Wang*; Lehui Xiao*; Yanjun Zhao*; Curved corannulene dually targets mitochondria and endoplasmic reticulum and initiates apoptosis via localized ROS induction upon light triggering. Materials Science & Engineering C-Materials for Biological Applications 2020, 106, 110227. (中科院2区,IF = 7.9)
5. Xuliang Guo; Qingyu Xing; Kunhua Lei; Daisy Zhang-Negrerie; Yunfei Du*; Kang Zhao*; A tandem ring opening/closure reaction in a BF3-mediated rearrangement of spirooxindoles. Advanced Synthesis & Catalysis, 2017, 359, 4393-4398.5. (中科院2区,IF = 5.0)